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Your body has the natural ability to heal itself with stem cells and their derivatives.

As you get older, the amounts of stem cells you have in your body are greatly reduced and are not as effective. With the advancements in science over the past 20 years, stem cells derived from placenta and umbilical cord has emerged as a key element of Cell Based Therapeutics.

Our Cell based products are derived from the human umbilical cord tissue that captures all the greatest reviving properties of this otherwise discarded tissue. Our brand of Cell based products uses a proprietary method of isolating growth factors, therapeutic cells and stem cells giving our patients the best possible benefits from a Sempiternal source. The cell derived product used in our clinic is produced in compliance with FDA as well as CDSCO cGMP (Current Good Manufacturing Practice) and GTP (Good Tissue Practices) standards, which assures quality and safety in this product.

Human hematopoietic stem cell transplantation is used to treat variety of conditions like genetic disorders that effects immune system, rescue following irradiation as a cancer treatment, autoimmune disorders and chronic infectious diseases.

There are two types of cell-based therapies:

Autologous: Cells extracted from patient and given back to the patient

Allogenic:  Cells extracted from a donor and administered to a patient with condition

The use of the above modes of therapy is subjective to the patient condition, age and other conditions. There is no one size fits all approach in cell-based therapies. For e.g., in children suffering from blood related disorders or MLD, autologous cell based therapy would be a tough deal as the children suffering from such immunological disorders would not be able to cope up to the pressure of autologous procedures. Allogenic procedures are the preferred means of option in such cases.

Prasad Hospital is along with Prasad research foundation offers the best cell based therapies for different conditions with the help of a board overseeing it. The team at Prasad Hospital and the foundation are working on developing hematopoietic cell based therapies in the below conditions:

  • Hemoglobinopathy (Blood related disorders like sickle cell anemia, thalassemia)
  • Psoriasis
  • Diabetic Foot Ulcer
  • Knee osteoarthritis
  • ASD(Autism)
  • Juvenile Arthritis
  • Lysosomal storage disease(like Metachromatic leukodystrophy(MLD)

What is Sickle Cell Anemia?

Sickle cell anaemia is to be an inborn error leading to the blood disorder, affecting many people in India. It is passed over to the child through affected or carrier parents. Sudies indicate that, if both the parents have contributed one affected gene to the child, there can be a possibility of synthesizing abnormal or sickle haemoglobin by the body.

Symptoms of sickle cell anemia:

  • Fatigue and anemia.
  • Pain crises.
  • Dactylitis (swelling and inflammation of the hands and/or feet) and arthritis.
  • Bacterial infections.
  • Sudden pooling of blood in the spleen and liver congestion.
  • Lung and heart injury.
  • Leg ulcers.

What is Thalassemia?

Thalassemia is another type of blood disorder that is caused by a defect in the gene that helps control the production of the globin chains that make up the hemoglobin molecule.

HOW STEM CELLS TREATMENT CAN HELP

The blood of a newborn’s umbilical cord is a rich source of hematopoietic stem cells for transplantation. Because the donor newborn’s immune system is still immature, the stem cells are less likely to induce an adverse immune reaction in the receiver, If the transplant is successful, the sickle cell patient may well be cured.

WHAT SETS US APART:

  • Best hematopoietic stem cells therapy for blood disorders
  • Board with the best dermatologists, clinicians and doctors overlooking the process
  • Ethics committee board overlooking the process from ethics perspective.
  • India’s best research and practice oriented stem-cell research practice

An autoimmune disease is a condition arising from an abnormal immune response to a body part. There are at least 80 types of autoimmune diseases.

A few diseases that are considered autoimmune include:

  • Rheumatoid arthritis
  • Diabetes mellitus type 1,
  • Multiple sclerosis
  • Graves’ disease,
  • Inflammatory bowel disease
  • Systemic lupus erythematosus.

Common symptoms of autoimmune disease include:

  • Fatigue
  • Joint pain and swelling
  • Skin problems
  • Abdominal pain or digestive issues
  • Recurring fever
  • Swollen glands

How Can Stem cell help:

Hematopoietic stem cell transplantation is a great option for patients with autoimmune diseases. HSC’s have the ability to modulate the immune system and preserves body’s ability to fight off disease. Mesenchymal stem cells home to infected body tissue and produces anti-inflammatory agents. These act locally and do not suppress the immune response of the patient’s whole body. The cells could be generated from unaffected individuals or, as predisposing genetic factors are defined, from umbilical cord or placenta cells lacking these genetic influences. In addition, use of genetically selected or genetically engineered cell types may further limit the possibility of disease progression or reemergence.

Treatment at Prasad Hospital:

Prasad Research foundation along with Prasad Hospital has a cross functional group of doctors, scientists, researchers and technicians which will evaluate the patient on a case by case and provides a holistic treatment with the help of novel medical technologies. The hospital is equipped with the best cell based therapy teams and a GMP standard facility for immunological diseases

WHAT SETS US APART

  • Prasad Research is the best stem cell therapy for auto immune disorders.
  • Medical Advisory Board comprising of luminaries from different research institutes.
  • Ethics committee oversees the ethics process.
  • India’s best research and practice oriented stem-cell research practice.

Autism spectrum disorders (ASDs) are characterized by deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs.

How Does Stem cell work in Autism :

Umbilical cord derived stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. ASD subjects show an imbalance in innate and adaptive immunity, as some forms of cells(CD3+ , CD4+ , Natural Killer and CD8+ T cells) are altered.

Stem cells have the below properties:

  • Immunomodulatory properties,
  • Repair and restoration of injured/inflamed neural cells.
  • Convert from pro-inflammatory cells to anti-inflammatory ones.
  • Long term engraftment

Follow up and regular review protocols are established and discussed across the ASD board to observe the improvements in the child’s neurological, Psycho, social and physical growth.

WHAT SETS US APART:

Prasad Hospital and Prasad Research foundation along with Prasad hospitals has the below:

    • An Autism board comprising psychologists, doctors, researchers which oversees the overall process
    • Prasad Research Foundation offers the best stem cell therapy for autism.
    • Ethics committee which is above the autism board monitoring the overall ethics in the process
    • A GMP standard facility culturing the cell
    • A NABH hospital which has the best infrastructure

Inborn errors of metabolism is a class of genetic diseases. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into others (products). In most of the disorders, problems arise due to accumulation of substances, which are toxic or interfere with normal function. Inborn errors of metabolism are also called congenital metabolic diseases or inherited metabolic disorders.

There are many types of inborn errors of metabolism.

  • Lysosomal storage disorders
  • Galactosemia
  • Maple sugar urine disease (MSUD)
  • Phenylketonuria (PKU)
  • Adrenoleukodystrophy
  • Metachromatic Leukodystrophy
  • Globoid Cell Leukodystrophy
  • Tay Sachs Disease
  • Sandhoffs Disease
  • Wolman Disease
  • I-Cell Disease
  • Sanfilippo Syndrome
  • GM1 Gangliosidosis

Symptoms of Inborn Errors of Metabolism:

  • Recurrent episodes of vomiting, ataxia, seizures, lethargy, coma or a mix of the above
  • Skeletal abnormalities and abnormalities of the hair or skin.
  • Poor feeding, failure to thrive.
  • Dilated heart condition,jaundice and liver dysfunction.
  • Developmental delay, occasionally with loss of milestones.
  • Ataxia, hypotonia or hypertonia and visual and auditory disturbances.

How can Stem cells help in IEM:

Allogeneic HSCT has largely contributed to the improved survival and quality of life of many children affected by IEMs

WHAT SETS US APART

  • Prasad Research offers the best stem cell therapy for IEM
  • Advisory board of pediatricians, geneticist and researchers
  • India’s best research and practice oriented stem-cell research practice

What’s rheumatoid arthritis?

Rheumatoid arthritis (RA) is an autoimmune disease that can cause joint pain and damage throughout your body. The joint damage that RA causes usually happens on both sides of your body. Treatments work best when RA is diagnosed early, so it’s important to learn the signs.

Rheumatoid arthritis symptoms

RA is a long-term or chronic disease marked by symptoms of inflammation and pain in the joints. RA symptoms, which can occur throughout the body, include:

  • joint pain
  • joint swelling
  • joint stiffness
  • loss of joint function
  • Pain can vary from mild to severe.

Rheumatoid arthritis diagnosis

Diagnosing RA can take time and may require multiple lab tests to confirm clinical examination findings. Prasad Hospital will ask about your symptoms and medical history. They’ll also perform a physical exam of your joints. This will include looking for swelling and redness, and testing your reflexes and muscle strength. Your doctor will also touch the affected joints to check for warmth and tenderness. If they suspect RA, they’ll most likely refer you to our specialist called a rheumatologist.

Since no single test can confirm a diagnosis of RA, doctor or rheumatologist may use several different types of tests. They may test your blood for certain substances like antibodies, or check the level of certain substances like acute phase reactants that are elevated during inflammatory conditions. These can be a sign of RA and help support the diagnosis.

They may also request certain imaging tests. Tests such as ultrasonography, x-ray exams, and magnetic resonance imaging (MRI) not only show if damage from RA has been done to your joints but also how severe the damage is. A complete evaluation and monitoring of other organ systems might be in order for some people with RA

How stem Cells work for Rheumatoid Arthritis:

Stem cells are the cells that are responsible for developing an entire human body from a tiny two-celled embryo; due to their unlimited divisions and strong power to differentiate into all the cells of different lineage. This power of stem cells is harnessed by technology to isolate them outside the human body, concentrate in the clean environment and implant back.

Stem cells treatment involves administration of concentrated cells in the targeted area(joints in the case of RA), wherein they can colonize in the damaged area, adapt the properties of resident stem cells and initiate some of the lost functions that have been compromised by the disease or injury. Stem cells possess properties to enhance the network of blood vessels. These stem cells regulate body’s immune system. These cells can regulate immune system and help promoting the hormonal balance back.

WHAT SETS US APART

  • Prasad Research is the best stem cell therapy for Rheumatoid Arthiritis
  • Medical Advisory Board comprising of luminaries from different research institutes
  • India’s best research and practice oriented stem-cell research practice

Graft versus host disease (GvHD) is a condition that might occur after a transplant. The donated bone marrow in the case of GvHD, or peripheral blood stem cells view the recipient’s body as foreign, and the donated cells/bone marrow attack the body.

Forms of GvHD

  • Acute graft versus host disease (aGvHD).
  • Chronic graft versus host disease (cGvHD).

As a transplant recipient, you might experience either form of GvHD, both forms.

Acute GvHD might occur once the donor’s cells have engrafted in the transplant recipient. It might develop in your skin, liver, eyes, or gastrointestinal tract, and symptoms might appear within weeks after your transplant.

Chronic GvHD can appear at any time after allogenic transplant or several years after your transplant. Chronic GvHD might occur in the skin, liver, eyes, mouth, lungs, gastrointestinal tract, neuromuscular system, or genitourinary tract.

 

Symptoms to report

Symptoms of acute GvHD might include any of the following:

  • Skin rash or reddened areas on the skin (signs of aGvHD of the skin)
  • Yellow discoloration of the skin and/or eyes, and abnormal blood test results (signs of aGvHD of the liver)
  • Nausea, vomiting, diarrhea, or abdominal cramping (signs of aGvHD in the gastrointestinal tract, or “gut”)
  • • Increased dryness/irritation of the eyes (signs of GvHD of the eyes)

Symptoms of chronic GvHD might include any of the following:

  • Rash, raised, or discolored areas, skin thickening or tightening (signs of cGvHD of the skin)
  • Abdominal swelling, yellow discoloration of the skin and/or eyes, and abnormal blood test results (signs of cGvHD of the liver)
  • Dry eyes or vision changes (signs of cGvHD of the eyes)
  • Dry mouth, white patches inside the mouth, pain or sensitivity to spicy foods (signs of oral cGvHD, of the mouth)
  • Shortness of breath or changes seen on your chest X-ray (signs of dry cough pulmonary cGvHD — of the lungs)
  • Difficulty swallowing, pain with swallowing, or weight loss (signs of cGvHD of the gastrointestinal tract or “gut”)
  • Fatigue, muscle weakness, or pain (signs of neuromuscular cGvHD, of the nerves and muscles)

HOW STEM CELLS TREATMENT MAY HELP!

A promising treatment option for aGVHD consists of infusion of bone marrow donor Mesenchymal Stromal Cells(MSC). MSCs have been used in the treatment of aGVHD due to their inhibitory effects on the proliferation and cytotoxic activity of immune system cells.

Prasad Research foundation cultures clinical grade best stem cell therapy for GvHD. We have the expertise of working with the best hematologists in providing the MSCs for GvHD.

WHAT SETS US APART

    • Best stem cell(MSC) for GvHD
    • Board with the best hematologists, clinicians and doctors overlooking the process
    • Ethics committee board overlooking the process from ethics perspective.
    • India’s best research and practice oriented stem-cell research practice

What is Diabetic foot ulcer?

Diabetic foot ulcer (DFU) is the most common complication of diabetes mellitus that usually fail to heal, and leading to lower limb amputation

 

 

 

Diabetic foot ulcers symptoms

  • Swelling, discoloration, and warmth around the wound.
  • Foul-smelling discharge seeping from the wound.
  • Pain and firmness when the wound is touched.
  • Callused or thickened skin surrounding the ulcer.
  • Fever and chills in advanced stages of foot ulcers.

How stem Cells work for Diabetic foot ulcer

Cell-based therapy has emerged as a promising therapeutic strategy to treat DFU. Allogeneic HSCT has largely contributed to prevent amputation and to promote wound healing. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote wound healing.

WHAT SETS US APART

  • Prasad Research is the best stem cell therapy to prevent amputation of DFU and improves wound healing
  • Institutional ethics committee will review to follow the institution specific guidelines
  • India’s best research and practice oriented stem-cell research practice

What is Juvenile Diabetes?

Type-1 diabetes in children is called juvenile diabetes or insulin dependent diabetes mellitus. It happens most often in children and young adults but can appear at any age

Juvenile Diabetes symptoms :

  • Being very thirsty
  • Urinating often
  • Feeling very hungry or tired
  • Losing weight without trying
  • Having sores that heal slowly
  • Having dry, itchy skin
  • Losing the sensation in feet or having tingling sensation in feet
  • Having blurry eyesight

Juvenile Diabetes Diagnosis

Diagnosing Juvenile Diabetes can take time and may require multiple lab tests to confirm clinical examination findings. Prasad Hospital will ask about your symptoms and medical history and also family history of diabetes. They may also request you to undergo certain tests such as –

    • A1C
    • Blood Glucose Test
    • Glucose in Urine Test
    • Glucose in Urine Test
    • Ketones in Blood
    • Ketones in Urine
    • Microalbumin Test

How stem Cells work on Juvenile Diabetes

The cell-based therapies at Prasad research foundation were aimed to down-regulate the immune system and to halt or abolish the autoimmune depletion of these cells. The stem cell generation and their differentiation into normally functioning insulin-secreting β-cells was focused to treat Juvenile diabetes. The stem cell therapy (SCT) is meant to improve the quality of life by achieving a normalized glycemic control, reducing side effects of synthetic immunosuppression and preventing diabetic complications.

WHAT SETS US APART

  • Prasad Research offers the best stem cell therapy for Juvenile Diabetes
  • Advisory board of pediatricians, geneticist and researchers
  • India’s best research and practice oriented stem-cell research practice

Dr.S.Raghavender

Dr.S.Raghavender

Medical coordinator

Dr.S.Raghavender

Dr.K Suma Prasad

Research coordinator

Shiva

Shiva Kumar

Lab Coordinator

Usharani

B Usha Rani

Nursing Coordinator

vikram

G Vikram Kumar Reddy

Quality Coordinator

ishwarya

T Ishwarya Rani

I C N Coordinator