Prasad Hospitals >> Thalassemia
Thalassemia is a type of blood disorder that is caused by a defect in the gene that helps in controlling the production of the globin chains that make up the hemoglobin molecule.
Thalassemia (thal-uh-SEE-me-uh), this inherited blood disorder is characterized by drop-in hemoglobin and fewer red blood cells in the body than usual. Hemoglobin, the substance in the red blood cells that enables them to transport oxygen, which in the case of thalassemia falls drastically causing anemia & fatigue.
In the case of mild thalassemia, treatment may not be required. Although if you observe a severe form of the disorder, regular blood transfusions may be required.
Various types of thalassemia exist, namely alpha-thalassemia, thalassemia intermedia, and Cooley anemia. The signs and symptoms depend on the type and severity of the patient’s condition. Where in some infants show signs and symptoms of thalassemia at birth, others may develop them with time over the first two years of life. However, people with only one affected hemoglobin gene do not usually experience any symptoms relating to thalassemia.
Hematopoietic stem cell (HSC) transplantation in cases of thalassemia has been the cornerstone in the development of HSCT. The cellular replacement therapy, although not limited to the diseased erythropoietic component, leads to the replacement of the complete hematopoietic system. In any case, as a productive method to acquire a long-lasting, probably permanent, clinically compelling correction of hemolytic anemia by maintaining a strategic distance from transfusion necessities and associated complications.
This approach in nonmalignant disease is highly different from transplantation in malignancies. In the previous setting, the detrimental immunologic properties of the engrafted HSC do not balance due to an anti-malignancy effect. Hence it must always be considered in determining the risk/benefit ratio and therapeutic decision. Prasad Hospitals, one of the Best Hospitals for Stem Cell Therapy For Thalassemia in Hyderabad, have treated many patients.
The blood of a newborn’s umbilical cord is a rich source of hematopoietic stem cells for transplantation. Because the donor newborn’s immune system is still immature, the stem cells are less likely to induce an adverse immune reaction in the receiver, If the transplant is successful, the sickle cell patient may well be cured.