Aging also effects hair loss. Premature hair loss in males and females has become a major aesthetic concern these days. Hair loss could be due to genetic predisposition, autoimmune, nutritional deficiencies, metabolic disorders, stress or drugs. Four stages of hair cycle are (1) anagen (growth), (2) catagen (regression), (3) telogen (rest), and (4) exogen (shedding). Wnt, hedgehog, transforming growth factor-β (TGF-β)/BMP, fibroblast growth factor (FGF), and tumor necrosis factor (TNF) paracrine signaling factors play a key role in hair cycle. The Hair follicle stem cells are located in the bulge region of outer root sheet and maintain hair follicle homeostasis through periodic cycling. The stem cells migrate to the base of the follicle, transform into “transiently activated matrix cells” capable of giving rise to all cell lineages of the mature hair follicle.

Hair regeneration therapy using PRP has become a routine therapy these days. PRP functions through activation of WNT/ β - Catenin signaling, AKT signaling and other essential pathways involved in hair regeneration by secreting various cytokines and growth factors like VEGF, IGF- 1, EGF and PDGF.

SuCharm ^TM contains numerous cytokines, growth factors (VEGF, EGF, IGF-1, HGF), and miRNAs (hsa-miR-21-5p, hsa-miR-100-5p) that trigger WNT/ β - Catenin signaling, AKT signaling similar pathways, Sonic Hedgehog (Shh) pathways involved in initiation of hair regeneration and induction of transition from the resting (telogen) to the growth stage (anagen) of the hair follicle cycle. SuCharm ^TMis a new clinical grade solution that helps in hair regeneration.