Endometrial damage is a major cause of female reproductive problems, manifested as menstrual abnormalities, infertility, recurrent pregnancy loss, and other complications. The human endometrium is a highly regenerative tissue that undergoes periodic proliferation, differentiation, and shedding in women of childbearing age. Endometrium is described as the “fertile ground” for embryo implantation. Adequate endometrial thickness is an essential factor for successful implantation and continuing pregnancy.

A stem cell niche, around the spiral blood vessels in the endometrium promotes endometrial cyclic regeneration. Recent studies show that stem cell application in endometrium helps to treat extensive intrauterine adhesions, endometrial thinning and scarring thereby improves menstruation and infertility. These stem cells‐mediated paracrine factors, participate in endometrial proliferation, angiogenesis, immunomodulation, and activate the stem cell niches.

HealGen contains various cytokines, growth hormones, exosomes and miRNAs which help in endometrial regeneration through similar paracrine signaling besides the advantage of being cell free and xenofree.