Osteoarthritis is a mechanical degenerative and inflammatory condition affecting articular cartilage, synovium and sub-chondral bone tissues. Intra-articular stem cell therapies have shown functional improvement and to reduce pain. These stem cells act via paracrine signaling through various cytokines, growth factors and ECM proteins. Analgesic effect of stem cells is mediated by down regulation of inflammatory mediators like nitric oxide, TNF-α, and IL-1. Chondrocyte regenerative effect is promoted through activation of Notch Signaling pathway, SMAD Signaling pathway through BMP-2, stimulating production of proteoglycans and type II collagen.

Avascular Necrosis is a progressive degenerative disease due to vascular insult to bone tissue leading to collapse and degeneration ultimately requiring total joint replacement. However, treatment with injection of stem cells along with core decompression procedure in early stages has shown to provide significant pain relief, improvement in function, and ultimately halt the progression of AVN. These positive results can be attributed to anti-inflammatory, angiogenic and tissue regeneration capabilities of stem cells.

Tenacity^TM is a cell free alternative derived from mesenchymal stromal cell, rich in miRNAs which are known to trigger the Notch, SMAD, WNT and Sonic Hedgehog pathways which promote tissue regeneration. It also contains various growth factors like VEGF, HGF, IGF-I which promote angiogenesis and thereby tissue healing. Tenacity^TM also contains various ECM proteins like MMPS, TIMPS and collagen precursors which help in reorganization of degenerated tissues. Also through its immune modulation effects, it has shown to exert anti-inflammatory effect and reduce tissue destruction.

Tenacity^TM is an advanced cell free solution that we offer for a degenerative disease like Osteoarthritis and Avascular Necrosis.