Aging is a complex, dynamic physiological process that occurs with time effecting internal and external organs as well. Skin aging manifests in the form of wrinkles, fine lines, irregular pigmentation, skin thickening etc. Various external factors like UV radiation, heat, smoke and pollutants cause skin aging. Histologically there is decrease in collagen and abnormal elastin fiber deposition causing wrinkle formation. UV radiation induces ROS formation and DNA damage, causing increased production of MMPs and decreased production of collagen in keratinocytes and fibroblasts. Decrease in hyaluronan, increase in inflammatory cytokines, increased neutrophils with proteolytic enzymes, imbalance between MMPs and TIMPs are the central aspects of skin aging. Topical retinoids, cosmeceuticals, growth factors, dermal fillers, lasers, mechanical resurfacing techniques like microdermabrasion are being used currently for skin rejuvenation.

In the quest for skin rejuvenation, stem cell and cell free therapies have emerged as an advanced alternatives. These therapies act by reduction of oxidative stress, increased Interleukin 1 Receptor Antagonist (IL-1Ra) concentration, lower activity of proteolytic enzymes with subsequent less degradation of collagen, hyaluronic acid and other components of the extracellular matrix, which explain improvements in skin. Growth factors like TGF-β, PDGF, VEGF present in cell free medium are known to further induce hyaluronic acid synthesis and collagen formation. These stem cell conditioned medium also trigger local stem cell niches and signaling pathways like Wnt/β-catenin, Shh, TGF-β pathways which play a major role in skin rejuvenation and hair regeneration

SuCharm^TM is a cell free product rich in protein, growth factors (IGF-1, HGF), ECM proteins like collagen precursors, MMPs and miRNAs which have shown to trigger pathways necessary for skin, organized deposition of collagen and ECM components. SuCharm ^TM is an advanced solution for reversing clinical signs of skin aging.