Psoriasis is a chronic autoimmune disease that most commonly presents with well demarcated erythematous papules and plaques with silvery white scales on skin usually on extensor surfaces and also affects the nails. Psoriasis is now considered as a systemic inflammatory disease with increased risk of developing cardiovascular disease, Diabetes mellitus, metabolic syndrome, depression, inflammatory bowel disease, fatty liver disease, arthritis etc. The pathogenesis of psoriasis is mediated by IL-17/IL-23 axis. Genetic, environmental, chemical, radiation triggers T cell (Th1) activation and Dendritic cells produce IL23, which activates Th17 cells that produce IL17 and proinflammatory cytokines (TNFα, IFγ, IL12). IL22 produced by Th17 and Th22 cells, stimulates the proliferation of keratinocytes and psoriatic plaques. Immunomodulatory Th2 and Treg cells are reduced in psoriatic patients.

Recent studies on the role of stem cell and stem cell conditioned medium have shown promising results in reducing the disease severity. The primary mechanism of the immunoregulatory actions of MSCs corresponds to paracrine signaling. MSC-conditioned medium improves the anti-inflammatory phenotype of human regulatory macrophages by downregulating IL-22 and IL-23, promotion of Treg differentiation, enhancement of T cell apoptosis, inhibition of Th1 ad Th17 differentiation.

HealGen is a unique clinical grade, cell free, Xeno-free product with potent immunomodulatory effect owing to various growth factors, cytokines, miRNAs, ECM proteins (Collagen precursors, MMPs) that are present in optimum composition. This product is given as a local infiltration/application for plaque psoriasis unlike the current available systemic immunomodulatory drugs and biologicals, hence offers a safer side effect profile. HealGen is an advanced cost effective, safe solution for psoriatic patients where other treatment modalities failed to give expected results.