Osteoarthritis (OA) is a common orthopedic problem with advancing age characterized by pain in the joints, deformity and disability. OA is now considered as an inflammatory condition, with degenerative changes in joint cartilage and the surrounding tissues. Platelet Rich Plasma and Stem cell therapy have shown promising results in reducing pain and cartilage regeneration and reorganization to some extent.

Avascular Necrosis (AVN) is another condition which is the death of bone tissue due to lack of blood supply. Core decompressions and vascular grafts and implants are standard surgical therapies for AVN. Stem cell injections along with core decompression in early stages of AVN have shown to slow down the progression and decreased the need for total joint replacements on long term follow up.

These regenerative effects of stem cells are now thought to be through the paracrine signaling by various factors secreted by stem cells.

Tenacity^TM is a cell free product derived from stem cells with various cytokines and growth factors which have shown to reduce inflammation in the joint, promote healing of local tissues like cartilage, synovium and ligament repair.Tenacity^TM is an advanced cell free alternative for degenerative orthopedic diseases like Osteoarthritis and Avascular Necrosis.